The Limits of Middle Babylonian Archives

This paper deals with the archives of the Middle Babylonian Period (1500-1000 BC) giving first an overview of the material, showing the limits of the existing and so far published texts and then trying to reconstruct lost archives with special help of material from outside the archives: the kudurru inscriptions on stone. The focus of the article is on real estate documents inside and outside the archives and the aim is to investigate whether there were restrictions on the sale of real estate property and whether the legal information found on the kudurru inscriptions can be used to reconstruct documents that must have existed in the archives

Hydration effects turn a highly stretched polymer from an entropic into an energetic spring

Polyethylene glycol (PEG) is a structurally simple and nontoxic water-soluble polymer that is widely used in medical and pharmaceutical applications as molecular linker and spacer. In such applications, PEG’s elastic response against conformational deformations is key to its function. According to text-book knowledge, a polymer reacts to the stretching of its end-to-end separation by a decrease in entropy that is due to the reduction of available conformations, which is why polymers are commonly called entropic springs. By a combination of single-molecule force spectroscopy experiments with molecular dynamics simulations in explicit water, we show that entropic hydration effects almost exactly compensate the chain conformational entropy loss at high stretching. Our simulations reveal that this entropic compensation is due to the stretching-induced release of water molecules that in the relaxed state form double hydrogen bonds with PEG. As a consequence, the stretching response of PEG is predominantly of energetic, not of entropic, origin at high forces and caused by hydration effects, while PEG backbone deformations only play a minor role. These findings demonstrate the importance of hydration for the mechanics of macromolecules and constitute a case example that sheds light on the antagonistic interplay of conformational and hydration degrees of freedom

Knowing minds: Linking early perspective taking and later metacognitive insight

Recent metacognitive research using a partial knowledge task indicates that a firm understanding of ‘knowing about knowing’ develops surprisingly late, at around 6 years of age. To reveal the mechanisms subserving this development, the partial knowledge task was used in a longitudinal study with 67 children (33 girls) as an outcome measure at 5;9 (years;months). In addition, first- and second-order false belief was assessed at 4;2, 5;0, and 5;9. At 2;6, perspective taking and executive abilities were evaluated. Metacognition at 5;9 was correlated with earlier theory of mind and perspective taking – even when verbal intelligence and executive abilities were partialled out. This highlights the importance of perspective taking for the development of an understanding of one’s own mind

DeepScribe: Localization and Classification of Elamite Cuneiform Signs Via Deep Learning

Twenty-five hundred years ago, the paperwork of the Achaemenid Empire was recorded on clay tablets. In 1933, archaeologists from the University of Chicago's Oriental Institute (OI) found tens of thousands of these tablets and fragments during the excavation of Persepolis. Many of these tablets have been painstakingly photographed and annotated by expert cuneiformists, and now provide a rich dataset consisting of over 5,000 annotated tablet images and 100,000 cuneiform sign bounding boxes. We leverage this dataset to develop DeepScribe, a modular computer vision pipeline capable of localizing cuneiform signs and providing suggestions for the identity of each sign. We investigate the difficulty of learning subtasks relevant to cuneiform tablet transcription on ground-truth data, finding that a RetinaNet object detector can achieve a localization mAP of 0.78 and a ResNet classifier can achieve a top-5 sign classification accuracy of 0.89. The end-to-end pipeline achieves a top-5 classification accuracy of 0.80. As part of the classification module, DeepScribe groups cuneiform signs into morphological clusters. We consider how this automatic clustering approach differs from the organization of standard, printed sign lists and what we may learn from it. These components, trained individually, are sufficient to produce a system that can analyze photos of cuneiform tablets from the Achaemenid period and provide useful transliteration suggestions to researchers. We evaluate the model's end-to-end performance on locating and classifying signs, providing a roadmap to a linguistically-aware transliteration system, then consider the model's potential utility when applied to other periods of cuneiform writing.Comment: Currently under review in the ACM JOCC

Interactions of Ionic Liquids and Spirocyclic Compounds with Liposome Model Membranes. A Steady-State Fluorescence Anisotropy Study

Understanding the toxicity of ionic liquids (ILs) is crucial in the search of greener chemicals. By comparing in vivo toxicity and in vitro interactions determined between compounds and biomimetic lipid membranes, more detailed toxicity vs. structure relation can be obtained. However, determining the interactions between non-surface-active compounds and liposomes has been a challenging task. Organisational changes induced by ILs and IL-like spirocyclic compounds within 1,6-diphenyl-1,3,5-hexatriene-doped biomimetic liposomes was studied by steady-state fluorescence anisotropy technique. The extent of organisational changes detected within the liposome bilayers were compared to the toxicity of the compounds determined using Vibrio Fischeri bacteria. Four liposome compositions made of pure 1-palmitoyl-2-oleyl-sn-glycero-3-phosphocoline (POPC) and mixtures of POPC, 1-palmitoyl-2-oleyl-sn-glycero-3-phosphoserine (POPS), and cholesterol (Chol) were tested as biomimetic models. Changes observed within the POPC/POPS/Chol 55:20:25 bilayers correlated the best with the toxicity results: ten out of twelve compounds followed the trend of increasing bilayer disorder - increasing toxicity. The study suggests that the toxicity of non-surface-active compounds is dependent on their ability to diffuse into the bilayers. The extent of bilayer's organisational changes correlates rather well with the toxicity of the compounds. Highly sensitive technique, such as fluorescence anisotropy measurements, is needed for detecting subtle changes within the bilayer structures.Peer reviewe